NarciclasineAn antiproliferative and pro-apoptotic inducer

Narciclasine (CAS 29477-83-6)

Narciclasine | CAS 29477-83-6 is rated 5.0 out of 5 by 1.
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Synonym: (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Application: An antiproliferative and pro-apoptotic inducer
CAS Number: 29477-83-6
Molecular Weight: 307.26
Molecular Formula: C14H13NO7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
239.41 °C (Predicted)
Boiling Point :
733.85 °C at 760 mmHg (Predicted)
Density :
1.85 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
Optical Activity :
α20/D +162º, c = 0.19 in methanol
IC50 :
Panel of 60 cancer cell lines: IC50 = 47 nM; MDA-MB-231 : IC50 = 5 nM (human); FaDu: IC50 = 8 nM (human); Daoy: IC50 = 22 nM (human); C32: IC50 = 25 nM (human); Yellow fever virus: IC50 = 0.006 ug.mL-1 (Yellow fever virus)
Ki Data :
Cytochrome P450 3A4: Ki= 630 nM (human)
pK Values :
pKa: 7.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
nwg
RTECS :
JI5000000
PubChem CID :
72376
MDL Number :
MFCD01729949
Beilstein Registry :
1087400
SMILES :
C1OC2=C(O1)C(=C3C(=C2)C4=C[C@@H]([C@H]([C@H]([C@@H]4NC3=O)O)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Hu Y; et al Hu Y; et al. (PubMed ID: 26232920) determined that Narciclasine influences the actin-based vesicle motility in vivo. -SCBT Publication Review
Date published: 2015-07-03
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