NaproxenA Cox-1 and Cox-2 inhibitor

Naproxen (CAS 22204-53-1)

Naproxen | CAS 22204-53-1 is rated 5.0 out of 5 by 1.
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Synonym: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic Acid;(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid
Application: A Cox-1 and Cox-2 inhibitor
CAS Number: 22204-53-1
Purity: ≥98%
Molecular Weight: 230.26
Molecular Formula: C14H14O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).


References

1. Kean, W.F., et al. 1989. J Pharm Sci. 78: 324-327. PMID: 2724096
2. Robich, M.P., et al. 2010. J Cardiovasc Pharmacol. [Epub ahead of print]. PMID: 20980915
3. Dimiza, F., et al. 2010. J Inorg Biochem. [Epub ahead of print]. PMID: 20926136
4. Takeda, T., et al. 2010. J Phys Chem B. [Epub ahead of print]. PMID: 20979356
5. Duggan, K.C., et al. 2010. J. Biol. Chem. 285: 34950-34959. PMID: 20810665

Physical State :
Solid
Solubility :
Soluble in water (>3 mg/mL) at 25° C, PBS pH 7.2, SOL., ethanol, DMSO, DMF (100 mg/mL), chloroform, dichloromethane, ether, ethyl acetate, methanol, and THF.
Storage :
Store at room temperature
Melting Point :
152-154° C (lit.)
Boiling Point :
~403.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61
Optical Activity :
α20/D 66°, c = 1 in chloroform
IC50 :
recombinant COX-1: IC50 = 0.6-4.8 µM (human); recombinant COX-2: IC50 = 2.0-28.4 µM (human)
pK Values :
pKa: 4.85
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UF5275000
PubChem CID :
156391
Merck Index :
14: 6417
MDL Number :
MFCD00010500
EC Number :
244-838-7
Beilstein Registry :
3591068
SMILES :
C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Naproxen, sc-200506 is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-05-26
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Rated 5 out of 5 by from Takeda et al Takeda et al. (PubMed ID 20979356) found that naproxen's anti-aggregation effect is due to its ability to destabilize A amyloid fibrils. -SCBT Publication Review
Date published: 2015-01-07
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