Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).
1. Kean, W.F., et al. 1989. J Pharm Sci. 78: 324-327. PMID: 2724096 2. Robich, M.P., et al. 2010. J Cardiovasc Pharmacol. [Epub ahead of print]. PMID: 20980915 3. Dimiza, F., et al. 2010. J Inorg Biochem. [Epub ahead of print]. PMID: 20926136 4. Takeda, T., et al. 2010. J Phys Chem B. [Epub ahead of print]. PMID: 20979356 5. Duggan, K.C., et al. 2010. J. Biol. Chem. 285: 34950-34959. PMID: 20810665
Soluble in water (>3 mg/mL) at 25° C, PBS pH 7.2, SOL., ethanol, DMSO, DMF (100 mg/mL), chloroform, dichloromethane, ether, ethyl acetate, methanol, and THF.
Rated 5 out of
Takeda et alTakeda et al. (PubMed ID 20979356) found that naproxen's anti-aggregation effect is due to its ability to destabilize A amyloid fibrils. -SCBT Publication Review
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