Naphthomycin BA naphthalenic ansamycin antbiotic isolated from Streptomyces

Naphthomycin B (CAS 86825-88-9)

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Application: A naphthalenic ansamycin antbiotic isolated from Streptomyces
CAS Number: 86825-88-9
Purity: >98%
Molecular Weight: 706.2
Molecular Formula: C39H44ClNO9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Naphthomycin B is a naphthalenic ansamycin antibiotic isolated from Streptomyces, reported to act against gram-positive bacteria and fungi. Napthomycins are ansa macrocyclic antimetabolites that have been described in studies to show high cytotoxic activity against various leukemic cells. Additionally, studies have proved that naphthomycin inhibits DNA and RNA synthesis in L5178Y cells.


References

1. Williams, T.H. 1975. J. Antibiot. 28: 85-86. PMID: 805115
2. Keller-Schierlein, W., et al. 1983. J. Antibiot. 36: 484-492. PMID: 6874565
3. Okabe, T., et al. 1985. J. Antibiot. 38: 230-235. PMID: 3997667

Physical State :
Solid
Derived From :
Streptomyces sp. Gö 40/14
Solubility :
Soluble in DMSO, methanol or acetone.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
OC1C=CC(C)C(O)C(C)C=C(C)C(=O)c2c3C(=O)C(=C(NC(=O)C=CC=CC=CC(C)C(O)CC(=O)C(=CC1)C)C(=O)c3cc(C)c2O)Cl

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Certificate of Analysis

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Naphthomycin B  Product Citations

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Citations 1 to 1 of 1 total

PMID: # 6874565  Keller-Schierlein, W. et al. 1983. J. Antibiot. 36: 484-492.

Citations 1 to 1 of 1 total
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