Naltrindole Hydrochloride is the hydrochloride salt preparation of Naltrindole, which is an apoptotic agent and an inhibitor of cell growth. Naltrindole has been shown to be a cell permeable, highly potent and selective antagonist of DOR(δ opioids). Mechanistic studies show that Naltrindole treatement reduces phosphorylation of threonine 308 and Akt/PKB on serine 473 in cells. By reducing phosphorylation of Akt/PKB, downstream effectors glycogen synthase kinase-3β and transcription factors such as AFX and FKHR are also reduced.
1. Portoghese, P.S., et al. 1991. J. Med. Chem. 34: 1715-1720. PMID: 1851846 2. Verborgh, C., et al. 1999. Pharmacol. Biochem. Behav. 63: 175-183. PMID: 10340539 3. Chen, Y.L., et al. 2004. Cancer Res. 64: 8723-8730. PMID: 15574783
Soluble in water (8 mg/ml), and methanol (4.5 mg/ml).
Store at -20° C
n20D 1.80 (Predicted)
Growth of NCI-H69: IC50 = 25 µM; Growth of NCI-H345: IC50 = 40 µM; Growth of NCI-H510 : IC50 = 55 µM
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Chen et alChen et al. (PubMed ID 15574783) used Naltrindole Hydrochloride to induce cell death by reducing phosphorylation of Akt/PKB in small cell lung cancer cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.