Naloxone hydrochlorideA nonspecific opiate receptor antagonist that displays anitnociceptive effects

Naloxone hydrochloride (CAS 357-08-4)

Naloxone hydrochloride | CAS 357-08-4 is rated 5.0 out of 5 by 1.
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Synonym: (5α)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Application: A nonspecific opiate receptor antagonist that displays anitnociceptive effects
CAS Number: 357-08-4
Molecular Weight: 363.84
Molecular Formula: C19H21NO4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Naloxone hydrochloride is a nonspecific opiate receptor antagonist that displays anitnociceptive effects. Studies have identified this product as a significant immunoadjuvant in cancer immunotherapy. Reportedly exhibits the ability to reverse various types of cardiovas Naloxone hydrochloride is an inhibitor of DOR, KOR, MOR and Sigma Receptor.


References

1. McNicholas, L.F., et al. 1984. Drugs. 27: 81-93. PMID: 6319107
2. Joshi, G.G., et al. 2009. Indian J Gastroenterol. 28: 180-182. PMID: 20107967
3. Molla Hassan, A.T., et al. 2009. Int. Immunopharmacol. 9: 1381-1386. PMID: 19706340
4. Tallett, A.J., et al. 2009. Pharmacol. Biochem. Behav. 91: 358-366. PMID: 18755211

Physical State :
Solid
Solubility :
Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml), and DMSO (73 mg/ml). Insoluble in ether.
Storage :
Store at 4° C
Melting Point :
182° C
Refractive Index :
n20D 1.69 (Predicted)
Optical Activity :
α20/D -160°, c = 0.5 in water
IC50 :
Adenosine A3-R: IC50 = 1.6 nM (human); MOR-1: IC50 = 2 nM (human); Mu opioid receptor : IC50 = 5 nM (bovine); Opioid receptors; mu/kappa/delta: IC50 = 43 nM (human); DOR-1: IC50 = 138 nM (human)
Ki Data :
Mu opioid receptor : Ki= 0.23 nM (rat); KOR-1: Ki= 0.25 nM (human); Mu opioid receptor : Ki= 0.68 nM (guinea pig); Mu opioid receptor : Ki= 1.07 nM (rat); Kappa opioid receptor: Ki= 3.17 nM (guinea pig)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QD2275000
PubChem CID :
5464092
Merck Index :
14: 6362
MDL Number :
MFCD00069322
EC Number :
206-611-0
Beilstein Registry :
6260807
SMILES :
C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Uskur Uskur, et al. (PubMed ID 26376284) found that when treating rats with just naloxone alone, no change in the conditioned place preference (CPP) was observed. However, a significant reversal in CPP was observed when pre-treating the rats with naloxone, followed by treatment with dexmedetomidine (DEX). -SCBT Publication Review
Date published: 2015-06-13
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