Naloxone hydrochloride is a nonspecific opiate receptor antagonist that displays anitnociceptive effects. Studies have identified this product as a significant immunoadjuvant in cancer immunotherapy. Reportedly exhibits the ability to reverse various types of cardiovas Naloxone hydrochloride is an inhibitor of DOR, KOR, MOR and Sigma Receptor.
1. McNicholas, L.F., et al. 1984. Drugs. 27: 81-93. PMID: 6319107 2. Joshi, G.G., et al. 2009. Indian J Gastroenterol. 28: 180-182. PMID: 20107967 3. Molla Hassan, A.T., et al. 2009. Int. Immunopharmacol. 9: 1381-1386. PMID: 19706340 4. Tallett, A.J., et al. 2009. Pharmacol. Biochem. Behav. 91: 358-366. PMID: 18755211
Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml), and DMSO (73 mg/ml). Insoluble in ether.
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UskurUskur, et al. (PubMed ID 26376284) found that when treating rats with just naloxone alone, no change in the conditioned place preference (CPP) was observed. However, a significant reversal in CPP was observed when pre-treating the rats with naloxone, followed by treatment with dexmedetomidine (DEX). -SCBT Publication Review
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