NadifloxacinA fluoroquinolone broad spectrum antibiotic

Nadifloxacin (CAS 124858-35-1)

Nadifloxacin | CAS 124858-35-1 is rated 5.0 out of 5 by 1.
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Synonym: 9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid; Jinofloxacin
Application: A fluoroquinolone broad spectrum antibiotic
CAS Number: 124858-35-1
Purity: >98%
Molecular Weight: 360.38
Molecular Formula: C19H21FN2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nadifloxacin is a cell-permeable, synthetic, broad-spectrum fluoroquinolone antibiotic that inhibits the growth of both gram-positive and gram-negative microbes. Studies suggest that the mechanism of inhibition occurs by interfering with DNA replication. Specifically Nadifloxacin suppresses gram-positive bacterial growth by targeting topoisomerase IV and suppresses gram-negative bacteria by inhibiting Topo II (DNA gyrase), which both function to relax postive supercoils before DNA replication. Furthermore, Nadifloxacin can decrease superoxide radical anions such as O2- and OH-, produced by neutrophils.


References

1. Akamatsu, H., et al. 1995. J. Int. Med. Res. 23: 19-26. PMID: 7774755
2. Kuwahara, K., et al. 2005. J. Dermatol. Sci. 38: 47-55. PMID: 15795123
3. Oppegard, L.M., et al. 2010. Antimicrob. Agents Chemother. 54: 3011-3014. PMID: 20404126

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
245-251° C
Boiling Point :
~624.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
DNA gyrase: IC50 = 10 ug.mL-1 (staphylococcus aureus subsp. aureus Mu50); Topoisomerase IV subunit A: IC50 >10 ug.mL-1 (staphylococcus aureus)
pK Values :
pKa: 5.65, pKb: 1.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4410
Merck Index :
14: 6345
MDL Number :
MFCD00865081
SMILES :
CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O

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Certificate of Analysis

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Nadifloxacin  Product Citations

See how others have used Nadifloxacin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26825118  Kamaruzzaman, NF. et al. 2016. The Journal of antimicrobial chemotherapy. 71: 1252-9.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Akamatsu et al Akamatsu et al. (PubMed ID 7774755) decreased superoxide radical anions (O2-) and hydroxyl radicals (OH.) generated by neutrophils. -SCBT Publication Review
Date published: 2015-03-14
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