N-SMase Spiroepoxide Inhibitor is a potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase). It has been suggested N-SMase Spiroepoxide Inhibitor binds to the active site of N-SMase, indicating that it can be used study the biological role and mechanism N-SMase. Additionally, use of N-SMase Spiroepoxide Inhibitor in HUVEC cells has displayed substantial suppression of IL-1β-induced TF protein formation confirming the involvement of nSMase in contributing to cellular increases of ceramide. N-SMase Spiroepoxide Inhibitor has also been used to inhibit exosome release during the isolation process of exosomes derived from HCV-infected hepatocytes.
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See how others have used N-SMase Spiroepoxide Inhibitor. Click on the entry to view the PubMed entry .
PMID: # 31242426 Borghesan, M.|Fafián-Labora, J.|Eleftheriadou, O.|Carpintero-Fernández, P.|Paez-Ribes, M.|Vizcay-Barrena, G.|Swisa, A.|Kolodkin-Gal, D.|Ximénez-Embún, P.|Lowe, R.|Martín-Martín, B.|Peinado, H.|Muñoz, J.|Fleck, RA.|Dor, Y.|Ben-Porath, I.|Vossenkamper, A.|Muñoz-Espin, D.|O'Loghlen, A.| et al. 2019. Cell Rep. 27: 3956-3971.e6.
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