N-(p-Coumaroyl) Serotonin is an antibacterial agent which inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes. It is believed that this inhibition is a result of the partial down-regulation of cytokine mRNA levels and inhibition of NF-κB activation. Studies indicate that serotonin is essential in protecting NK cells from apoptosis. In addition, these studies show that N-(p-Coumaroyl) Serotonin is essential in the oxidation of unsaturated fatty acids. N-(p-Coumaroyl) Serotonin functions as an antioxidant, inhibiting the effects of high glucose-induced cell death, caspase-9 activation, and the overproduction of the mitochondrial superoxide.
1. Takii, T., et al. 2003. Int. Immunopharmacol. 3: 273-277. PMID: 12586608 2. Piga, R., et al. 2009. Br. J. Nutr. 102: 264-272. PMID: 19222875 3. Piga, R., et al. 2010. Br. J. Nutr. 103: 25-31. PMID: 19747415
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PigaPiga, R. et al. (PubMed 19747415) investigated the protective effects of serotonin derivatives on glucose-induced damage in PC12 rat pheochromocytoma cells. They found that N-(p-Coumaroyl) Serotonin exerted a protective effect on high glucose-induced cell death, inhibited the activation of caspase-3, and inhibited the overproduction of the mitochondrial superoxide. -SCBT Publication Review
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