N-Oleoyldopamine (OLDA) is an endogenous lipid compund in the mammalian brain. It has been found to be a VR1 (TRPV1) activator and potent 5-LO inhibitor. Activation of the VR1 receptor induces glutamate release and paraventricular nucleus postsynaptic firing. OLDA has been reported to induce the influx of calcium in VR1-transfected human embryonic kindey 293 cells. It has also been reported to induce the accumulation of cAMP in GPR119-transfected cells. OLDA has been also been observed to stimulate the release of insulin in HIT-T15 cells that endogenously express GPR119.
1. Chu, C.J., et al. 2003. J. Biol. Chem. 278: 13633-13639. PMID: 12569099 2. Li, D.P., et al. 2004. J. Neurophysiol. 92: 1807-1816. PMID: 15115794 3. Chu, Z.L., et al. 2010. Mol. Endocrinol. 24: 161-170. PMID: 19901198
It is not recommended to store solutions for more than 1 day.
Soluble in DMSO (≥20 mg/ml), DMF (~20 mg/ml), ethanol (50 mM), and ethanol: PBS pH 7.2 (1:1) (500 µg/ml).
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