N-Methyl-L-tyrosineA tyrosine hydroxylase inhibitor

N-Methyl-L-tyrosine (CAS 537-49-5)

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Synonym: N-Me-Tyr-OH·HCl
Application: A tyrosine hydroxylase inhibitor
CAS Number: 537-49-5
Molecular Weight: 195.22
Molecular Formula: C10H13NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Methyl-L-tyrosine is a TH (tyrosine hydroxylase) inhibitor, which suppresses the formation of DOPA from L-tyrosine. Tyrosine hydroxylase functions as an oxygenase, which is found in the cytosol of cells containing catecholamines. Inhibition of the enzyme leads to the depletion of dopamine and norepinephrine, as a result of the decrease in L-DOPA concentration. Furthermore, N-Methyl-L-tyrosine can be useful in research, which requires a regulation of tyrosine hydroxylase.


References

1. Kaufman, S. 1995. Adv. Enzymol. Relat. Areas Mol. Biol. 70: 103-220. PMID: 8638482
2. Nagatsu, T. 1995. Essays Biochem. 30: 15-35. PMID: 8822146
3. Hedstrand, H., et al. 2000. Biochem. Biophys. Res. Commun. 267: 456-461. PMID: 10623641

Physical State :
Solid
Solubility :
Soluble in water (1 g/l), aqueous acid, aqueous base, and alkaline.
Storage :
Store at room temperature
Melting Point :
253-256° C (dec.)
Boiling Point :
~378.8° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +16.0°±1.0°, c = 1 in 1M HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
68309
Merck Index :
14: 9007
MDL Number :
MFCD00238322
EC Number :
208-670-8
Beilstein Registry :
2646795
SMILES :
CN[C@@H](CC1=CC=C(O)C=C1)C(O)=O

Download SDS (MSDS)

Certificate of Analysis

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