N-Methyl-D-Aspartic acid (NMDA) CAS: 6384-92-5
MF: C5H9NO4
MW: 147.1
A definitiveionotropic NMDA receptor agonist.

N-Methyl-D-Aspartic acid (NMDA) (CAS 6384-92-5)

N-Methyl-D-Aspartic acid (NMDA) | CAS 6384-92-5 is rated 5.0 out of 5 by 1.
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Application: N-Methyl-D-Aspartic acid (NMDA) is a definitiveionotropic NMDA receptor agonist
CAS Number: 6384-92-5
Purity: ≥98%
Molecular Weight: 147.1
Molecular Formula: C5H9NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel closely involved in memory, in spatial learning and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.


References

1. Watkins, J.C., et al. 1981. Annu. Rev. Pharmacol. Toxicol. 21: 165-204. PMID: 6112965
2. Hansen, J.J., et al. 1990. Med Res Rev. 10: 55-94. PMID: 2153264
3. Cain, D.P. 1998. Neurosci Biobehav Rev. 22: 181-193. PMID: 9579310
4. Manfridi, A., et al. 1999. Am. J. Physiol. 277: R1488-R1492. PMID: 10564223

Physical State :
Solid
Solubility :
Soluble in water (100 mM ), dilute aqueous base, and ethanol.
Storage :
Store at room temperature
Melting Point :
189-190° C
Boiling Point :
~258.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.49
Optical Activity :
α20/D -15°, c = 2 in water
IC50 :
Glutamate NMDA receptor: IC50 = 4150 nM (rat); Glutamate NMDA receptor: EC5050 = 6860 nM (rat); Glutamate (NMDA) receptor subunit zeta 1: EC5050 = 8300 nM (rat)
Ki Data :
Displacement of [3H]CGS19755 from excitatory NMDA receptor: Ki= 4200 nM ; Displacement of [3H]CGP39653 from NMDA receptor: Ki= 6200 nM (Sprague-Dawley rat brain membranes)
pK Values :
pKa: 2.21, pKb: 9.96
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CI9457000
PubChem CID :
Merck Index :
14: 6662
MDL Number :
MFCD00004226
EC Number :
227-012-0
Beilstein Registry :
1724431
SMILES :
CN[[email protected]](CC(=O)O)C(=O)O

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N-Methyl-D-Aspartic acid (NMDA) (CAS 6384-92-5)  Product Citations

See how others have used N-Methyl-D-Aspartic acid (NMDA) (CAS 6384-92-5). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30771294  2019. Exp. Eye Res. 181: 208-212.

PMID: # 31504901  Poult. Sci.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Various publications cite N Various publications cite N-Methyl-D-Aspartic acid (NMDA) as a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. -SCBT Publication Review
Date published: 2015-03-04
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