N-Methyl-1H-imidazole-4-ethanamine dihydrochloride CAS: 16503-22-3
MF: C6H11N3•2HCl
MW: 198.09
A potent histamine receptor agonist.

N-Methyl-1H-imidazole-4-ethanamine dihydrochloride (CAS 16503-22-3)

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Application: A potent histamine receptor agonist
CAS Number: 16503-22-3
Molecular Weight: 198.09
Molecular Formula: C6H11N32HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Methyl-1H-imidazole-4-ethanamine dihydrochloride is a potent histamine receptor agonist, especially at Histamine H3 receptors (potency relative to histamine is 81, 185, and 270% at Histamine H1, Histamine H2 and Histamine H3 respectively). Displays agonist properties at Histamine H4 receptors to which it binds with moderate affinity (Ki = 23 nM).


1. Schwartz, J.C., et al. 1990. Agents Actions. 30: 13-23.
2. Hill, S.J. 1990. Pharmacol. Rev. 42: 45-83.
3. Zweig, A., et al. 1992. J. Neurochem. 59: 1661-1666.

Physical State :
Solubility :
Soluble in water (100 mM).
Storage :
Store at room temperature
Melting Point :
172-174° C
Refractive Index :
n20D 1.53
Ki Data :
Displays agonist properties at H4 receptors to which it binds with moderate affinity: Ki= 23 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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Certificate of Analysis

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Shouldn't the CAS reference be 16503-22-3 if the compound is the dihydrochloride form?

Asked by: Jan_S
Thank you for your question. Yes, 16503-22-3 is the correct CAS number for this chemical. We will update this information on our website.
Answered by: Technical Support
Date published: 2017-08-02
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