N-glycolylneuraminic acid (Neu5Gc) is a hydroxylated form of the generally known sialic acid N-acetylneuraminic acid, Neu5Ac (sc-281055). The compound is biosynthesized by the activity of cytidine monophosphate-N-acetylneuraminate (CMP-Neu5Ac) hydroxylase. Humans do not express Neu5Gc because there is an absence of the hydroxylase acitivity required to convert CMP-Neu5Ac to CMP-Neu5Ac. This is due to a mutation in the gene that occurred after the Homo-Pan divergence. Research shows that the parasite Trypanosoma cruzi contains N-glycoloylneuraminic acid, but is unable to synthesize sialic acids from their precursors.
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PMID: # 26295436 Badr, HA. et al. 2015. Biomaterials. 70: 23-36.
PMID: # 9751737 Chou, HH. et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 11751-11756.
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