N-Formyl-Met-Leu-PheAn inducer of superoxide release and agonist for FPR1

N-Formyl-Met-Leu-Phe (CAS 59880-97-6)

N-Formyl-Met-Leu-Phe | CAS 59880-97-6 is rated 5.0 out of 5 by 1.
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Synonym: Formyl-Met-Leu-Phe-OH; Chemotactic Peptide
Application: An inducer of superoxide release and agonist for FPR1
CAS Number: 59880-97-6
Purity: ≥97%
Molecular Weight: 437.55
Molecular Formula: C21H31N3O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide for polymorphonuclear leukocyte and has been shown to stimulate aggregation of leukocytes. N-Formyl-Met-Leu-Phe induces superoxide release from neutrophils. N-Formyl-Met-Leu-Phe is also an agonist for the FPR (formyl peptide receptor 1) (Ki = 38 nM).


References

1. Bautista, A.P. and Elliott, K.E. 1994. Life Sci. 54: 721-730. PMID: 8107522

Physical State :
Solid
Sequence :
fMet-Leu-Phe-OH
Solubility :
Soluble in water (partly), methanol, DMSO (4 mg/ml), ethanol (2 mg/ml), and DMF (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
215° C
Boiling Point :
783.51° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α20/D -10°, c = 0.5 in acetic acid
IC50 :
FPR: EC5050 = 10 nM (human); FPR: IC50 = 20 nM (human); FPR3: EC5050 = 1.9 µM (human); FPR2: EC5050 = 20.4 µM (human)
Ki Data :
FPR: Ki= 38 nM
pK Values :
pKa: 3.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SQ7342000
PubChem CID :
443295
MDL Number :
MFCD00036780
EC Number :
264-899-3
Beilstein Registry :
2315783
SMILES :
CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CCSC)NC=O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from N N-Formyl-Met-Leu-Phe reported in many articles as a continuous activator of formyl peptide receptors in neutrophils. -SCBT Publication Review
Date published: 2015-01-02
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