N-Arachidonoyl-L-serine is an endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. Binds weakly to CB1 and CB2 receptors and TRPV1. Produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein.
1. Milman, G., et al. 2006. Proc Natl Acad Sci USA. 103: 2428-2433. PMID: 16467152
Oil or viscous
Soluble in DMSO (≥20 mg/ml), DMF (≥20 mg/ml), PBS (pH 7.2) (≥2 mg/ml), water (2 mg/ml at 25.0° C), and ethanol.
Store at -80° C
n20D 1.52 (Predicted)
CB1: Ki>10 µM (human); CB2: Ki>10 µM (human)
pKa: 3.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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