N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium SaltA bacterial, viral, and mammalian neuraminidase inhibitor

N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt (CAS 24967-27-9)

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Application: A bacterial, viral, and mammalian neuraminidase inhibitor
CAS Number: 24967-27-9
Purity: ≥95%
Molecular Weight: 313.24
Molecular Formula: C11H16NNaO8
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt is an inhibitor of bacterial, viral, and mammalian neuraminidases (KI = 4 μM for influenza virus neuraminidase). N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt is believed to act by binding to the catalytic site of neuraminidase as a transition state analog.


References

1. Chong, A K., et al., 1991. Characterisation of an ionisable group involved in binding and catalysis by sialidase from influenza virus. Biochemistry international. 24(1): 165-71. PMID: 1768256
2. Holzer, C T., et al., 1993. Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position. Glycoconjugate journal. 10(1): 40-4. PMID: 8358225
3. Kopitz, J., et al., 1997. Effects of cell surface ganglioside sialidase inhibition on growth control and differentiation of human neuroblastoma cells. European journal of cell biology. 73(1): 1-9. PMID: 9174666

Physical State :
Solid
Solubility :
Soluble in water (1 mM).
Storage :
Store at -20° C
Ki Data :
neuraminidase: Ki= 4 µM (influenza virus )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71776143
SMILES :
CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@@H]([C@@H](CO)O)O)C(=O)[O-])O.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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