N-Acetyl-Asp-Glu-OHAn endogenous neurotransmitter with high affinity for mGluR-3

N-Acetyl-Asp-Glu-OH (CAS 3106-85-2)

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Synonym: α-NAAG; Spaglumic acid
Application: An endogenous neurotransmitter with high affinity for mGluR-3
CAS Number: 3106-85-2
Purity: ≥98%
Molecular Weight: 304.26
Molecular Formula: C11H16N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Acetyl-Asp-Glu-OH is an endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR-2 and mGluR-3. N-Acetyl-Asp-Glu-OH is an mGluR3 activator and an weak activator of NMDA receptor.


References

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2. Koller, K.J., et al. 1984. Eur. J. Pharmacol. 98: 193-199. PMID: 6143677
3. Blakely R.D. and Coyle, J.T. 1988. Int. Rev. Neurobiol. 30: 39-100. PMID: 3061970
4. Jackson, P.F., et al. 1996. J. Med. Chem. 39: 619-622. PMID: 8558536
5. Coyle, J.T. 1997. Neurobiol. Dis. 4: 231-238. PMID: 9361299
6. Ghose, S., et al. 1997. J. Neurochem. 69: 2326-2335. PMID: 9375663
7. Orlando, L.R., et al. 1997. Neurosci. Lett. 236: 91-94. PMID: 9404819
8. Passani, L.A., et al. 1997. Mol. Chem. Neuropathol. 31: 97-118. PMID: 9376025
9. Passani, L.A., et al. 1997. Brain Res. 772: 9-22. PMID: 9406950

Physical State :
Solid
Solubility :
Soluble in water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5255
SMILES :
CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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