N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.
1. Palacios, M., et al. 1989. Biochem. Biophys. Res. Commun. 165: 802-809. PMID: 2480784
2. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101: 746-752. PMID: 1706208
3. McCall, T.B., et al. 1991. Br. J. Pharmacol. 102: 234-238. PMID: 1710525
4. Moore, W.M., et al. 1994. J. Med. Chem. 37: 3886-3888. PMID: 7525961
See how others have used N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO). Click on the entry to view the PubMed entry .
PMID: # 27158388 Xu, Z. et al. 2016. Am J Transl Res. 8: 1027-36.
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