N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)An inhibitor of NOS3

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) (CAS 150403-88-6)

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) | CAS 150403-88-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_16, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200343, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 176ms
  • REVIEWS, PRODUCT
Synonym: L-NIO hydrochloride;L-Ornithine ψ-acetamidine hydrochloride
Application: An inhibitor of NOS3
CAS Number: 150403-88-6
Purity: ≥95%
Molecular Weight: 209.67
Molecular Formula: C7H15N3O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.


References

1. Palacios, M., et al. 1989. Biochem. Biophys. Res. Commun. 165: 802-809. PMID: 2480784
2. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101: 746-752. PMID: 1706208
3. McCall, T.B., et al. 1991. Br. J. Pharmacol. 102: 234-238. PMID: 1710525
4. Moore, W.M., et al. 1994. J. Med. Chem. 37: 3886-3888. PMID: 7525961

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml)
Storage :
Store at -20° C
Melting Point :
220-222° C
Refractive Index :
n20D 1.54
IC50 :
Nitric oxide synthase, inducible: IC50 = 4000 nM (human); Nitric-oxide synthase, brain: IC50 = 9000 nM (human); Nitric-oxide synthase, endothelial: IC50 = 6000 nM (human); Nitric oxide synthase, inducible: IC50 = 9000 nM (Mus musculus)
Ki Data :
recombinant NOS: Ki= 100 nM (human); Nitric-oxide synthase, brain: Ki= 230 nM (human); Nitric oxide synthase, inducible: Ki= 340 nM (human); Nitric-oxide synthase, endothelial: Ki= 810 nM (human)
pK Values :
pKa: 2.49, pKb: 12.34
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
177903
MDL Number :
MFCD00153817
SMILES :
CC(=NCCC[C@@H](C(=O)O)N)N.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)  Product Citations

See how others have used N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27158388  Xu, Z. et al. 2016. Am J Transl Res. 8: 1027-36.

Citations 1 to 1 of 1 total

I would like to know if it is possible to use in drinking water for animals ?

Asked by: Pawlab
Thank you for your inquiry. Please call us toll-free at (800) 457-3801 option 2, e-mail <scbt@scbt.com>, or use the live chat on our website.
Answered by: Technical Support 10
Date published: 2017-09-21
  • y_2019, m_9, d_16, h_14CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_200343, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 123ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Van Slooten Van Slooten, AR. et al. (PubMed 25745859) presented N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. -SCBT Publication Review
Date published: 2015-04-14
  • y_2019, m_9, d_16, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200343, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 32ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.