N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]ureaCAS: 330796-24-2
MF: C23H15ClF4N4O2
MW: 490.84
A hedgehog inhibitor.

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea (CAS 330796-24-2)

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Application: A hedgehog inhibitor
CAS Number: 330796-24-2
Molecular Weight: 490.84
Molecular Formula: C23H15ClF4N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea is a cell-permeable quinazolinyl-urea icompound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay. It is a potent modulator of Hedgehog (Hh) protein function and a nanomolar hedgehog antagonist.


References

Chiang, C., et al.: Nature, 383, 407 (1996), Hahn, H., et al.: Cell, 85, 841 (1996), Johnson, R.L., et al.: Science, 272, 1668 (1996), St.-Jacques, B., et al.: Genes Dev., 13, 2072 (1999),

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9913498
SMILES :
C1=CC=C2C(=C1)C(=O)N(C(=N2)CNC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)C4=CC=C(C=C4)F

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Certificate of Analysis

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