N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea is a cell-permeable quinazolinyl-urea icompound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay. It is a potent modulator of Hedgehog (Hh) protein function and a nanomolar hedgehog antagonist.
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