Myosmine is a minor tobacco alkaloid which has been shown to possess genotoxic effects on cells through DNA damage by pyridyloxobutylation. Studies indicate that in cells Myosmine can be activated into reactive intermediates by H2O2 (sc-203336) and 3-morpholinosydnonimine (sc-200339). It is known that under acidic pH Myosmine undergoes a ring-chain tautomerism and is present in the amino-keto form. Furthermore, Myosmine is an ideal tool to use to monitor the effects of tobacco smoke on cells.
1. Zwickenpflug, W. and Tyroller, S. 2006. Chem. Res. Toxicol. 19: 150-155. PMID: 16411668 2. Havla, J.B., et al. 2009. Food Chem. Toxicol. 47: 237-241. PMID: 19041922 3. Jiang, E., et al. 2009. Mutat. Res. 672: 60-64. PMID: 19007910
Soluble in Ether, Ethyl Acetate, Methanol and Water
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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We are interested in 2-kilos of pure Myosmine. Please advise best price and terms
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MoghbelMoghbel, N. et al. (PubMed 26114650) developed a reversed-phase HPLC-UV method for the separation and quantitation of six target alkaloids from leaves of Nicotiana species (nicotine, nornicotine, anatabine, anabasine, Myosmine, and cotinine). -SCBT Publication Review
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