Myoseverin ia a microtubule-binding molecule that induces reversible fission of multinucleated myotubules into mononucleated fragments. Induces changes in the expression levels of genes implicated in extracellular matrix remodeling, inflammation, coagulation, signal transduction, and cell communication such as those seen in the wounding response of fibroblasts.
Rosania, G.R., et al. 2000. Nat. Biotechnol. 18, 304
Soluble in DMSO (100 mg/ml), and chloroform (50 mg/ml).
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Jung et alJung et al. (PubMed ID 21322636) found that Myoseverin, an inducer of multinucleated myotubule fission, induced optimal fiber cellularization and enhanced proliferative response in amphibian skeletal muscle. -SCBT Publication Review
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