MyoseverinAn inducer of multinucleated myotubule fission

Myoseverin (CAS 267402-71-1)

Myoseverin | CAS 267402-71-1 is rated 5.0 out of 5 by 1.
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Synonym: 9-Isopropyl-N2,N6-bis-(4-methoxybenzyl)-9H-purine-2,6-diamine
Application: An inducer of multinucleated myotubule fission
CAS Number: 267402-71-1
Purity: ≥98%
Molecular Weight: 432.52
Molecular Formula: C24H28N6O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Myoseverin ia a microtubule-binding molecule that induces reversible fission of multinucleated myotubules into mononucleated fragments. Induces changes in the expression levels of genes implicated in extracellular matrix remodeling, inflammation, coagulation, signal transduction, and cell communication such as those seen in the wounding response of fibroblasts.


References

Rosania, G.R., et al. 2000. Nat. Biotechnol. 18, 304

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), and chloroform (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
266.39° C (Predicted)
Boiling Point :
~661.30° C at 760 mmHg (Predicted)
Density :
~1.24 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
SW48: IC50 = 2.7 µM (human); HCT-116: IC50 = 3.3 µM (human); CEM : IC50 = 5.7 µM (human); Tubulin alpha-1 chain : IC50 = 8.0 µM (Bos taurus); Tubulin beta chain: IC50 = 8.0 µM (Bos taurus)
pK Values :
pKb: 4.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4273
MDL Number :
MFCD02683596
SMILES :
CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=C(C=C3)OC)NCC4=CC=C(C=C4)OC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jung et al Jung et al. (PubMed ID 21322636) found that Myoseverin, an inducer of multinucleated myotubule fission, induced optimal fiber cellularization and enhanced proliferative response in amphibian skeletal muscle. -SCBT Publication Review
Date published: 2015-01-20
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