MT-21 (CAS 186379-49-7)
Alternate Names:
N-Octyl-3-acetyl-4,5-dimethyl-5-hydroxy-3-pyrrolin-2-one
Application:
MT-21 is a cell-permeable apoptosis inducing agent that causes release of cytochrome c
CAS Number:
186379-49-7
Molecular Weight:
281.4
Molecular Formula:
C16H27NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MT-21 is a cell-permeable antitumor agent that induces apoptosis (~40 μM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (ΔΨm) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells. MT-21 is an activator of caspase-3, JNK and Krs.
References
1. Kakeya, H. et al. 1997. J. Med. Chem. 40(4): 391-394. PMID: 9046328
2. Watabe, M. et al. 1999. Oncogene. 18(37): 5211-5220. PMID: 10498871
3. Watabe, M. et al. 2000. Cancer Res. 60(18): 5214-5222. PMID: 11016650
Physical State
:
Low-Melting Solid
Solubility
:
Soluble in DMSO, and ethanol.
Storage
:
Store at -20° C
Melting Point
:
42-45° C
Boiling Point
:
470.99° C at 760 mmHg (Predicted)
Density
:
1.05 g/mL (Predicted)
Refractive Index
:
n20D 1.50 (Predicted)
pK Values
:
pKa: 11.73 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID
:
MDL Number
:
MFCD00953859
SMILES
:
CCCCCCCCN1C(=O)C(=C(C1(C)O)C)C(=O)C
Download SDS (MSDS)
Certificate of Analysis
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