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MT-21 is a cell-permeable antitumor agent that induces apoptosis (~40 μM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (ΔΨm) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells. MT-21 is an activator of caspase-3, JNK and Krs.
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