MT-21A cell-permeable apoptosis inducing agent that causes release of cytochrome c

MT-21 (CAS 186379-49-7)

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Synonym: N-Octyl-3-acetyl-4,5-dimethyl-5-hydroxy-3-pyrrolin-2-one
Application: A cell-permeable apoptosis inducing agent that causes release of cytochrome c
CAS Number: 186379-49-7
Molecular Weight: 281.4
Molecular Formula: C16H27NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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MT-21 is a cell-permeable antitumor agent that induces apoptosis (~40 μM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (ΔΨm) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells. MT-21 is an activator of caspase-3, JNK and Krs.


References

1. Kakeya, H. et al. 1997. J. Med. Chem. 40(4): 391-394. PMID: 9046328

2. Watabe, M. et al. 1999. Oncogene. 18(37): 5211-5220. PMID: 10498871

3. Watabe, M. et al. 2000. Cancer Res. 60(18): 5214-5222. PMID: 11016650

Physical State :
Low-Melting Solid
Solubility :
Soluble in DMSO, and ethanol.
Storage :
Store at -20° C
Melting Point :
42-45° C
Boiling Point :
470.99° C at 760 mmHg (Predicted)
Density :
1.05 g/mL (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
pK Values :
pKa: 11.73 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4262
MDL Number :
MFCD00953859
SMILES :
CCCCCCCCN1C(=O)C(=C(C1(C)O)C)C(=O)C

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Certificate of Analysis

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