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MSDH-C is a potent inhibitor of glycosphingolipid biosynthesis. At 10 μM decreases de novo ceramide biosynthesis by about 90%.
 Synthesis of potential inhibitors of the glycosphingolipid biosynthesis: G. Brenner-Weiss, et al.; Tetrahedron 48, 5855 (1992)  1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis: G. van Echten-Deckert, et al.; J. Biol. Chem. 273, 1184 (1998)
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