MSDH-CA potent inhibitor of glycosphingolipid biosynthesis

MSDH-C (CAS 144474-37-3)

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Synonym: D-erythro-1-Methylthiohydroceramide
Application: A potent inhibitor of glycosphingolipid biosynthesis
CAS Number: 144474-37-3
Molecular Weight: 387.7
Molecular Formula: C22H45NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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MSDH-C is a potent inhibitor of glycosphingolipid biosynthesis. At 10 μM decreases de novo ceramide biosynthesis by about 90%.


References

[1] Synthesis of potential inhibitors of the glycosphingolipid biosynthesis: G. Brenner-Weiss, et al.; Tetrahedron 48, 5855 (1992) [2] 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis: G. van Echten-Deckert, et al.; J. Biol. Chem. 273, 1184 (1998)

Physical State :
Solid
Solubility :
Soluble in DMSO or methanol.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10000297
SMILES :
CCCCCCCCCCCC(=O)N[C@@H](CSC)[C@@H](CCCCCC)O

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Certificate of Analysis

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