MRT 10CAS: 330829-30-6
MF: C24H23N3O5S
MW: 465.52
A Smo receptor antagonist and inverse agonist to nontranscriptional hedghog pathway activation.

MRT 10 (CAS 330829-30-6)

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Synonym: N-[[[3-[(Benzoyl)amino]phenyl]amino](thioxo)methyl]-3,4,5-trimethoxybenzamide
Application: A Smo receptor antagonist and inverse agonist to nontranscriptional hedghog pathway activation
CAS Number: 330829-30-6
Molecular Weight: 465.52
Molecular Formula: C24H23N3O5S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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MRT 10 is a Smo receptor antagonist with an IC50 value of 0.5 µM in HEK293 cells expressing murine Smo. MRT 10 also inhibits ShhN-induced Gli luciferase reporter activity in Shh-light2 cells with an IC50 value of 2.5 µM. MRT 10 also acts as an inverse agonist during to the nontranscriptional hedgehog pathway activation also in HEK293 cells with an IC50 value of 2.5 µM.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (≥15 mg/mL).
Storage :
Desiccate at 4° C
IC50 :
Smo: IC50 = 0.3 µM (human); Shh-induced Gli-reporter activity in Shh-light2 cells: IC50 = 0.64 µM
pK Values :
pKb: 0.23 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
1139102
MDL Number :
MFCD02734587
SMILES :
COC1=CC(=CC(=C1OC)OC)C(=O)NC(=S)NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3

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Certificate of Analysis

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