MRS 3777 hemioxalateA high affinity Adenosine A3-R antagonist

MRS 3777 hemioxalate

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Application: A high affinity Adenosine A3-R antagonist
Purity: ≥99%
Molecular Weight: 354.39
Molecular Formula: C17H19N5O•½C2H2O41/4H20
* Refer to Certificate of Analysis for lot specific data (including water content).
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MRS 3777 hemioxalate is a high affinity Adenosine A3-R antagonist (Ki = 47 nM) that displays > 200-fold selectivity versus Adenosine A1-R, Adenosine A2A-R and Adenosine A2B-R.


References

Perreira et al (2005) "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J.Med.Chem. 48 4910. Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247. Moro et al (2006) Progress in the pursuit of therapeutic adenosine receptor antagonists. Med.Res.Rev. 26 131.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.69 (Predicted)
Ki Data :
Adenosine A3 receptor: Ki= 47 nM; Adenosine A2a receptor: Ki= >10 µM (human); Adenosine A1 receptor: Ki= >10 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
OC(=O)C(=O)O.c1ccc(cc1)Oc1nc(NC2CCCCC2)c2nc[nH]c2n1c1ccc(cc1)Oc1nc(NC2CCCCC2)c2nc[nH]c2n1

Download SDS (MSDS)

Certificate of Analysis

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MRS 3777 hemioxalate  Product Citations

See how others have used MRS 3777 hemioxalate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23355189  da Rocha Lapa, F. et al. 2013. Purinergic Signal. 9: 325-36.

Citations 1 to 1 of 1 total
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