MRS 2690A potent agonist of the GPR105 receptor

MRS 2690 (CAS 15039-58-4)

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Synonym: Diphosphoric acid 1-α-D-glucopyranosyl ester 2-[(4'-methylthio)uridin-5''-yl] ester disodium salt
Application: A potent agonist of the GPR105 receptor
CAS Number: 15039-58-4
Purity: ≥98%
Molecular Weight: 626.33
Molecular Formula: C15H22N2Na2O16P2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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MRS 2690 is a potent GPR105 (P2Y14) receptor agonist (EC50 = 49 nM) that displays 7-fold higher potency than UDP-glucose.


References

Ko et al (2007) Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J.Med.Chem. 50 2030.

Physical State :
Solid
Solubility :
Soluble in whate (100 mM).
Storage :
Desiccate at -20° C
IC50 :
P2Y14: EC5050 = 49 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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