MRS 2578 CAS: 711019-86-2
MF: C20H20N6S4
MW: 472.66
A selective P2Y66 receptor antagonist.

MRS 2578 (CAS 711019-86-2)

MRS 2578 | CAS 711019-86-2 is rated 5.0 out of 5 by 1.
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Application: MRS 2578 is a selective P2Y66 receptor antagonist
CAS Number: 711019-86-2
Purity: ≥96%
Molecular Weight: 472.66
Molecular Formula: C20H20N6S4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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MRS 2578, a symmetric aryl diisothiocyanate derivative, is shown to be an inhibitor of P2Y6 receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions. P2Y receptor activation has been reported to induce phospholipase C activity. Further studies reveal that P2Y6 receptors can cause microglial phagocytosis as well as activation of P38 MAPK and expression of COX-2 in cells exposed to UVB radiation. MRS 2578 is an inhibitor of P2Y66.


References

1. Mamedova, L.K., et al. 2004. Biochem. Pharmacol. 67: 1763-1770. PMID: 15081875
2. Koizumi, S., et al. 2007. Nature. 446: 1091-1095. PMID: 17410128
3. Takai, E., et al. 2010. Radiat Res. [Epub ahead of print]. PMID: 21189077

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Desiccate at -20° C
Melting Point :
277.77° C (Predicted)
Boiling Point :
652.66° C at 760 mmHg (Predicted)
Density :
1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
P2Y6: IC50 = 37 nM
pK Values :
pKa: 11.8 (Predicted), pKb: 1.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD07370141
SMILES :
C1=CC(=CC(=C1)NC(=S)NCCCCNC(=S)NC2=CC=CC(=C2)N=C=S)N=C=S

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Certificate of Analysis

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MRS 2578 (CAS 711019-86-2)  Product Citations

See how others have used MRS 2578 (CAS 711019-86-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23899344  Shi, K.|Queiroz, KC.|Stap, J.|Richel, DJ.|Spek, CA.| et al. 2013. J Thromb Haemost. 11: 1892-902.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from determined that MRS 2578 significantly decreased determined that MRS 2578 significantly decreased the uptake of [3H]2-deoxyglucose in mouse C2C12 myotubes and 3T3-L1 adipocytes. -SCBT Publication Review
Date published: 2015-07-09
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