MRS 1220CAS: 183721-15-5
MF: C21H14ClN5O2
MW: 403.83
A highly potent and selective human Adenosine A3-R antagonist.

MRS 1220 (CAS 183721-15-5)

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Synonym: 9-Chloro-2-(2-furanyl)-5-((phenylacetyl)amino)-[1,2,4]triazolo[1,5-c]quinazoline
Application: A highly potent and selective human Adenosine A3-R antagonist
CAS Number: 183721-15-5
Molecular Weight: 403.83
Molecular Formula: C21H14ClN5O2
* Refer to Certificate of Analysis for lot specific data (including water content).

MRS 1220 is a potent and highly selective antagonist at the human Adenosine receptor (A3-R) (Ki values are 0.65, 305, and 52 nM at human Adenosine A3-R, rat Adenosine A1-R and rat Adenosine A2A-R, respectively. This compound displays an IC50 value > 1 μM for inhibition). Has shown to reverse the effect of A3 agonist elicited inhibition of tumor necrosis factor-alpha formation in human macrophage U-937 cell line.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM with gentle warming). Insoluble in water, and ethanol.
Storage :
Store at room temperature
Melting Point :
244-245° C
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
Adenosine A3-R: IC50 = 7.2 nM (human); Reversed the effect of A3 agonist-elicited inhibition of tumor necrosis factor-alpha formation : IC50 = 0.3 µM (human macrophage U-937 cell line); A3 receptors: IC50 >1 µM (rat)
Ki Data :
Adenosine A3-R: Ki= 0.65 nM (human); Adenosine A2a receptor: Ki= 10.3 nM (rat); Adenosine A2A-R: Ki= 25 nM (human); Adenosine A1 receptor: Ki= 52.7 nM (rat)
pK Values :
pKa: 8.18 (Predicted), pKb: 0.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
393595
MDL Number :
MFCD01321046
SMILES :
C1=CC=C(C=C1)CC(=O)NC2=NC3=C(C=C(C=C3)Cl)C4=NC(=NN42)C5=CC=CO5

Download SDS (MSDS)

Certificate of Analysis

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