MRS 1191CAS: 185222-90-6
MF: C31H27NO4
MW: 477.55
Adenoside A3 receptor antagonist.

MRS 1191 (CAS 185222-90-6)

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Synonym: 3-Ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate
Application: Adenoside A3 receptor antagonist
CAS Number: 185222-90-6
Molecular Weight: 477.55
Molecular Formula: C31H27NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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A selective A3 adenosine receptor antagonist. Selective for both human and rat.


References

Jiang, et al., 6-Phenyl-14-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists. J. Med. Chem. 39, 4667-4675, (1996) Jacobson, et al., Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology 36, 1157-1165, (1997) Dunwiddie, et al., Activation of hippocampal adenosine A3 receptors produces a desensitization of A1receptor-mediated responses in rat hippocampus. J. Neurosci. 17, 607-614, (1997) Naunyn Schmiedebergs Arch. Pharmacol. 361, 225-234, (2000) Peng, S. C. et al Eur. J. Pharmacol. 492, 49-55, (2004) Neurosci. Lett., 52-57, (2001)

Physical State :
Solid
Solubility :
Soluble in DMSO: >10 mg/mL: ethanol: >10 mg/mL: water: insoluble
Storage :
Store at -20° C
Melting Point :
155-156° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
393594
SMILES :
CCOC(=O)C1=C(NC(=C(C1C#CC2=CC=CC=C2)C(=O)OCC3=CC=CC=C3)C4=CC=CC=C4)C

Download SDS (MSDS)

Certificate of Analysis

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