MRN-ATM Pathway Inhibitor, Mirin, has been shown to prevent Mre11-Rad50-Nbs1 (MRN)-dependent activation of ataxia-telangiectasia mutated (ATM) without affecting ATM protein kinase activity. Mirin inhibits MRN by blocking the nuclease activity of Mre11, which in turn prevents the MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Other experiments have noted that inhibiting Mre11 also causes a reduction in the efficiency of non-homologous end joining. The MRN-ATM pathway has been reported to be essential for DNA damage detection and maintenance of genome stability during DNA replication. This pathway also promotes homology-dependent DNA repair, activates ATM, and is essential for cell viability. In vitro, mirin has been shown to induce cell-cycle arrest at the G2 phase, override the G2/M checkpoint, and inhibit homology-directed DNA repair.
1. Dupré, A., et al. 2008. Nat. Chem. Biol. 4: 119-125. PMID: 18176557 2. Roques, C., et al. 2009. EMBO J. 28: 2400-2413. PMID: 19609304 3. Rass, E., et al. 2009. Nat. Struct. Mol. Biol. 16: 819-824. PMID: 19633668
Soluble in DMSO (>10 mg/mL), ethanol (0.25 mg/mL), and DMF (30 mg/mL). Insoluble in water.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.