MRN-ATM Pathway Inhibitor, MirinAn inhibitor of Mre-11 and cell cycle arresting compound

MRN-ATM Pathway Inhibitor, Mirin (CAS 299953-00-7)

MRN-ATM Pathway Inhibitor, Mirin | CAS 299953-00-7 is rated 5.0 out of 5 by 1.
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Synonym: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-on
Application: An inhibitor of Mre-11 and cell cycle arresting compound
CAS Number: 299953-00-7
Purity: >95%
Molecular Weight: 220.35
Molecular Formula: C10H8N2O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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MRN-ATM Pathway Inhibitor, Mirin, has been shown to prevent Mre11-Rad50-Nbs1 (MRN)-dependent activation of ataxia-telangiectasia mutated (ATM) without affecting ATM protein kinase activity. Mirin inhibits MRN by blocking the nuclease activity of Mre11, which in turn prevents the MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Other experiments have noted that inhibiting Mre11 also causes a reduction in the efficiency of non-homologous end joining. The MRN-ATM pathway has been reported to be essential for DNA damage detection and maintenance of genome stability during DNA replication. This pathway also promotes homology-dependent DNA repair, activates ATM, and is essential for cell viability. In vitro, mirin has been shown to induce cell-cycle arrest at the G2 phase, override the G2/M checkpoint, and inhibit homology-directed DNA repair.


References

1. Dupré, A., et al. 2008. Nat. Chem. Biol. 4: 119-125. PMID: 18176557
2. Roques, C., et al. 2009. EMBO J. 28: 2400-2413. PMID: 19609304
3. Rass, E., et al. 2009. Nat. Struct. Mol. Biol. 16: 819-824. PMID: 19633668

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/mL), ethanol (0.25 mg/mL), and DMF (30 mg/mL). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
171.45° C (Predicted)
Boiling Point :
441.56° C at 760 mmHg (Predicted)
Density :
1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
prevents MRN-mediated activation of dimeric ATM: IC50 = 12 µM (cell-free p53 Ser15); MRN-dependent phosphorylation of histone H2AX: IC50 = 66 µM (human)
pK Values :
pKa: 8.71 (Predicted), pKb: 1.00 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1206243
MDL Number :
MFCD05885480
SMILES :
N=C1S/C(=C\\c2ccc(O)cc2)/C(=O)N1

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Certificate of Analysis

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MRN-ATM Pathway Inhibitor, Mirin  Product Citations

See how others have used MRN-ATM Pathway Inhibitor, Mirin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26317467  2015. Cell. 162: 987-1002.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Shah Shah, et al. (PubMed ID 26317467) reported that mirin (SCBT, sc-203144) does not prevent ATM activation in WT-virus-infected A549 cells. -SCBT Publication Review
Date published: 2015-06-07
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