MPP+ iodide is a metabolite of dopaminergic neurotoxin MPTP which stimulates the production of the superoxide radical resulting in apoptosis in PC12 cells. Studies suggest that MPP+ iodide is a selective inhibitor of mitochondrial complex I and it decreases mitochondrial REDOX activity. In addition, GSK-3β is a mediator of MPP+ iodide induced neurotoxicity. Alternate studies indicate that the D-loop of human mtDNA is destabilized by MPP+ iodide via releasing the nascent H-strands of mtDNA.
1. Umeda, S., et al. 2000. Eur. J. Biochem. 267: 200-206. PMID: 10601867
2. Nakai, M., et al. 2003. Exp. Neurol. 179: 103-110. PMID: 12504872
3. Yin, W.L., et al. 2009. Life Sci. 85: 269-275. PMID: 19540852
4. Petit-Paitel, A., et al. 2009. PLoS ONE. 4: e5491. PMID: 19430525
See how others have used MPP+ iodide (CAS 36913-39-0). Click on the entry to view the PubMed entry .
PMID: # 30521940 Chang, J.|Zhang, XL.|Yu, H.|Chen, J.| et al. 2019. Brain Res. Bull. 146: 1-6.