MPP+ iodide CAS: 36913-39-0
MF: C12H12IN
MW: 297.14
An active metabolite of the dopaminergic neurotoxin MPTP.

MPP+ iodide (CAS 36913-39-0)

MPP+ iodide | CAS 36913-39-0 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-Methyl-4-phenylpyridinium iodide
Application: MPP+ iodide is an active metabolite of the dopaminergic neurotoxin MPTP
CAS Number: 36913-39-0
Purity: ≥98%
Molecular Weight: 297.14
Molecular Formula: C12H12IN
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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MPP+ iodide is a metabolite of dopaminergic neurotoxin MPTP which stimulates the production of the superoxide radical resulting in apoptosis in PC12 cells. Studies suggest that MPP+ iodide is a selective inhibitor of mitochondrial complex I and it decreases mitochondrial REDOX activity. In addition, GSK-3β is a mediator of MPP+ iodide induced neurotoxicity. Alternate studies indicate that the D-loop of human mtDNA is destabilized by MPP+ iodide via releasing the nascent H-strands of mtDNA.


References

1. Umeda, S., et al. 2000. Eur. J. Biochem. 267: 200-206. PMID: 10601867
2. Nakai, M., et al. 2003. Exp. Neurol. 179: 103-110. PMID: 12504872
3. Yin, W.L., et al. 2009. Life Sci. 85: 269-275. PMID: 19540852
4. Petit-Paitel, A., et al. 2009. PLoS ONE. 4: e5491. PMID: 19430525

Physical State :
Solid
Solubility :
H2O: >10 mg/mL, soluble
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group II
PubChem CID :
SMILES :
C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

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MPP+ iodide (CAS 36913-39-0)  Product Citations

See how others have used MPP+ iodide (CAS 36913-39-0). Click on the entry to view the PubMed entry .

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PMID: # 30521940  Chang, J.|Zhang, XL.|Yu, H.|Chen, J.| et al. 2019. Brain Res. Bull. 146: 1-6.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Ahn Ahn, TB. et al. (PubMed 26330835) studied the neuroprotective role of quercetin against various toxins such as 1-Methyl-4-phenylpyridinium iodide (MPP+ iodide), an active metabolite of the dopaminergic neurotoxin MPTP. -SCBT Publication Review
Date published: 2015-07-10
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