MPEP hydrochlorideCAS: 96206-92-7
MF: C14H11N•HCl
MW: 229.71
A selective antagonist of the mGluR5 receptor.

MPEP hydrochloride (CAS 96206-92-7)

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Synonym: 6-Methyl-2-(phenylethynyl)-pyridine HCl; 2- methyl- 6- (2- phenylethynyl)- pyridine, monohydrochloride
Application: A selective antagonist of the mGluR5 receptor
CAS Number: 96206-92-7
Purity: ≥98%
Molecular Weight: 229.71
Molecular Formula: C14H11N•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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MPEP hydrochloride is a potent and selective antagonist of the mGluR5 receptor (metabotropic glutamate receptor subtype 5). MPEP hydrochloride positively modulates the hmGluR4 in a recombinant expression system, and the effect of MPEP hydrochloride is fully dependent on the activation of the orthosteric agonist L-AP4. MPEP hydrochloride reduces DHPG-induced excitations but not the excitations induced by AMPA. MPEP hydrochloride is an activator of mGluR-4.

Physical State :
Solid
Solubility :
Soluble in water (5 mM), ethanol (100 mM), and DMSO (100 mM).
Storage :
Desiccate at 4° C
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
GluR-5: IC50 = 36 nM; Plasmodium falciparum: IC50 = 12.59 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9794588
MDL Number :
MFCD02262119
SMILES :
CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl

Download SDS (MSDS)

Certificate of Analysis

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