Monoacylglycerol Lipase Inhibitor, URB602A cell-permeable N-biphenyl carbamate compound

Monoacylglycerol Lipase Inhibitor, URB602 (CAS 565460-15-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 62ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: N-[1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester
Application: A cell-permeable N-biphenyl carbamate compound
CAS Number: 565460-15-3
Molecular Weight: 295.38
Molecular Formula: C19H21NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Monoacylglycerol Lipase Inhibitor, URB602 is a cell-permeable N-biphenyl carbamate compound that has been found to act as a non-competitive and selective inhibior of Monoglyceride Lipase (monoacylglycerol lipase, MAGL). Monoacylglycerol Lipase Inhibitor, URB602 has not been found to inhibit FAAH, COX-2, or diacylglycerol lipase activity. Monoacylglycerol Lipase Inhibitor, URB602 has been shown to increase antinociception induced by stress, most likely through increasing 2-arachidonylglycerol levels.


References

1. Hohmann, A.G., et al. 2005. Nature. 435: 1108-1112. PMID: 15973410
2. Desroches, J., et al. 2008. Br. J. Pharmacol. 15: 913-924. PMID: 18695638
3. Muccioli, G.G., et al. 2008. Neuropharmacology. 54: 16-22. PMID: 17631917
4. Nallapaneni, A., et al. 2008. Neurotoxicology. 29: 1037-1043. PMID: 18765251

Physical State :
Solid
Solubility :
Soluble in DMSO (920 mg/ml), 100% ethanol (10 mg/ml), DMF (30 mg/ml), and 1:1 solution in DMSO:PBS, pH 7.2 (0.25 mg/ml).
Storage :
Store at 4° C
Melting Point :
153.48° C (Predicted)
Boiling Point :
~416.6° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
FAAH: IC50 = 5.65 µM (human); Monoglyceride lipase: IC50 = 10 µM (human)
pK Values :
pKa: 13.63 (Predicted), pKb: 0.06 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10979337
MDL Number :
MFCD08457914
SMILES :
C1CCC(CC1)OC(=O)NC2=CC=CC(=C2)C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 61ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.