Monoacylglycerol Lipase Inhibitor, URB602A cell-permeable N-biphenyl carbamate compound

Monoacylglycerol Lipase Inhibitor, URB602 (CAS 565460-15-3)

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Synonym: N-[1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester
Application: A cell-permeable N-biphenyl carbamate compound
CAS Number: 565460-15-3
Molecular Weight: 295.38
Molecular Formula: C19H21NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Monoacylglycerol Lipase Inhibitor, URB602 is a cell-permeable N-biphenyl carbamate compound that has been found to act as a non-competitive and selective inhibior of Monoglyceride Lipase (monoacylglycerol lipase, MAGL). Monoacylglycerol Lipase Inhibitor, URB602 has not been found to inhibit FAAH, COX-2, or diacylglycerol lipase activity. Monoacylglycerol Lipase Inhibitor, URB602 has been shown to increase antinociception induced by stress, most likely through increasing 2-arachidonylglycerol levels.


1. Hohmann, A.G., et al. 2005. Nature. 435: 1108-1112. PMID: 15973410
2. Desroches, J., et al. 2008. Br. J. Pharmacol. 15: 913-924. PMID: 18695638
3. Muccioli, G.G., et al. 2008. Neuropharmacology. 54: 16-22. PMID: 17631917
4. Nallapaneni, A., et al. 2008. Neurotoxicology. 29: 1037-1043. PMID: 18765251

Physical State :
Solubility :
Soluble in DMSO (920 mg/ml), 100% ethanol (10 mg/ml), DMF (30 mg/ml), and 1:1 solution in DMSO:PBS, pH 7.2 (0.25 mg/ml).
Storage :
Store at 4° C
Melting Point :
153.48° C (Predicted)
Boiling Point :
~416.6° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
FAAH: IC50 = 5.65 µM (human); Monoglyceride lipase: IC50 = 10 µM (human)
pK Values :
pKa: 13.63 (Predicted), pKb: 0.06 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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