Monensin AA broad-spectrum anticoccicidial antibiotic also exhibiting antifungal and antiviral activity

Monensin A (CAS 17090-79-8)

Monensin A | CAS 17090-79-8 is rated 5.0 out of 5 by 1.
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Synonym: Monensic acid
Application: A broad-spectrum anticoccicidial antibiotic also exhibiting antifungal and antiviral activity
CAS Number: 17090-79-8
Purity: ≥95%
Molecular Weight: 670.87
Molecular Formula: C36H62O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin is a broad-spectrum anticoccicidial antibiotic also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in the treatment of animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (limited).
Storage :
Store at -20° C
Melting Point :
103-105° C
Boiling Point :
~766.3° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3
Refractive Index :
n20D 1.55
Optical Activity :
α20D 47.7°
IC50 :
Plasmodium yoelii yoelii: IC50 <0.001 nM; Plasmodium falciparum NF54 schizonts: IC50 = 0.001 nM; Plasmodium berghei: IC50 = 0.6 nM; HepG2: IC50 > 100 µM (human)
pK Values :
pKa: 4.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
JH2829500
PubChem CID :
441145
MDL Number :
MFCD00799192
EC Number :
241-154-0
SMILES :
CC[C@]1(CC[C@@H](O1)[C@@]2(CC[C@@]3(O2)C[C@@H]([C@H]([C@H](O3)[C@@H](C)[C@H]([C@H](C)C(=O)O)OC)C)O)C)[C@H]4[C@H](C[C@@H](O4)[C@@H]5[C@H](C[C@H]([C@@](O5)(CO)O)C)C)C

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Certificate of Analysis

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Rated 5 out of 5 by from Ivanova Ivanova, et al. (PubMed ID 26109887) studied the effects of monensin on renal and cardiac functions of mice that have undergone intoxication by subacute cadmium exposure. -SCBT Publication Review
Date published: 2015-05-21
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