MNS (CAS 1485-00-3)

(0)

Write a review Ask a question

See product citations (1)

Alternate Names: Syk Inhibitor III

Application: MNS is a selective inhibitor of Syk kinase activity

CAS Number: 1485-00-3

Purity: ≥99%

Molecular Weight: 193.16

Molecular Formula: C₉H₇NO₄

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Click on image or enlarge button to enlarge

MNS is a selective inhibitor of c-Src and Syk tyrosine kinases also known as 3,4-methylenedioxy-β-nitrostyrene. MNS acts as a cell-permeable cytotoxic β-nitrostyrene derivative which suppresses human platelet aggregation. In addition, platelets previously aggregated by ADP, U46619, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu can be disaggregated by MNS. Studies suggest the mechanism responsible for this inhibition is observed via prevention of glycoprotein IIb/IIIa activation.

References

1. Wang, W.Y., et al. 2006. Mol. Pharmacol. 70: 1380-1389. PMID: 16837624
2. Hsieh, P.W., et al. 2010. Bioorg. Med. Chem. 18: 7621-7627. PMID: 20850977

Physical State :

Solid

Solubility :

DMSO

Storage :

Store at -20° C

Melting Point :

159-163° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

RTECS :

WL5270000

PubChem CID :

672296

SMILES :

C1OC2=C(O1)C=C(C=C2)C=C[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

MNS (CAS 1485-00-3) Product Citations

See how others have used MNS (CAS 1485-00-3). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26690982 Kondo, K. et al. 2015. PLoS ONE. 10: e0144803.