MMP Inhibitor V (CAS 223472-31-9)
MMP Inhibitor V is used for testing effective treatment of MMP-related diseases. MMP Inhibitor V, also called ONO-4817 is a cell permeable non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13, but not MMP-1, MMP-7, or other serine proteases. Widely used in studying MMP-mediated disease development. Also reported to block P-LAP secretase activity that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
References
1. Yamada, A., et al. 2000. Inflamm. Res. 49: 144-146. PMID: 10858013
2. Mori, T., et al. 2001. Exp. Biol. Med. 226: 429-433. PMID: 11393170
3. Shiraga, M., et al. 2002. Cancer Res. 62: 5967-5973. PMID: 12384564
4. Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314: 1008-1013. PMID: 14751233
5. Okamoto, Y., et al. 2007. Int Heart J. 48: 369-378. PMID: 17592201
Download SDS (MSDS)
SAMPLE Certificate of Analysis (COA)
MMP Inhibitor V | CAS 223472-31-9 SAMPLE Certificate of AnalysisCertificate of Analysis
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Appearance | Off white solid | |
| Identification (NMR) | Complies | |
| Purity (HPLC) | ≥ 98% | 98.17% |
| Solubility | DMSO (30 mg/ml) or ethanol (15 mg/ml) |
TEST CONDITIONS
Exp. Date: 3/16/2026
MMP Inhibitor V (CAS 223472-31-9) Product Citations
See how others have used MMP Inhibitor V (CAS 223472-31-9). Click on the entry to view the PubMed entry .
PMID: 34293080 | CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy. | Abu El-Asrar, AM. et al. 2021. Invest Ophthalmol Vis Sci. 62: 32.
PMID: 22234699 | p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes. | Anur, P. et al. 2012. Blood. 119: 1992-2002.