MMP Inhibitor VCAS: 223472-31-9
MF: C22H28N2O6
MW: 416.47
A broad-spectrum inhibitor of MMPs.

MMP Inhibitor V (CAS 223472-31-9)

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Synonym: ONO 4817; (2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide
Application: A broad-spectrum inhibitor of MMPs
CAS Number: 223472-31-9
Purity: ≥98%
Molecular Weight: 416.47
Molecular Formula: C22H28N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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MMP Inhibitor V is used for testing effective treatment of MMP-related diseases. MMP Inhibitor V, also called ONO-4817 is a cell permeable non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13, but not MMP-1, MMP-7, or other serine proteases. Widely used in studying MMP-mediated disease development. Also reported to block P-LAP secretase activity that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.


1. Yamada, A., et al. 2000. Inflamm. Res. 49: 144-146. PMID: 10858013
2. Mori, T., et al. 2001. Exp. Biol. Med. 226: 429-433. PMID: 11393170
3. Shiraga, M., et al. 2002. Cancer Res. 62: 5967-5973. PMID: 12384564
4. Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314: 1008-1013. PMID: 14751233
5. Okamoto, Y., et al. 2007. Int Heart J. 48: 369-378. PMID: 17592201

Physical State :
Solubility :
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage :
Store at 4° C
Melting Point :
284.22° C (Predicted)
Boiling Point :
653.32° C (Predicted)
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
MMP-1: IC50 = 1.6 µM
Ki Data :
MMP-12: Ki= 0.45 nM; MMP-2: Ki= 0.73 nM; MMP-8: Ki= 1.1 nM; MMP-13: Ki= 1.1 nM; MMP-9: Ki= 2.1 nM; MMP-3: Ki= 42 nM; MMP-7: Ki= 2.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
CCOCOC[[email protected]](C[[email protected]](C)C(=O)NO)NC(=O)C1=CC=C(C=C1)OC2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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