MMP Inhibitor II CAS: 203915-59-7
MF: C21H27N3O8S2
MW: 513.6
A potent and reversible inhibitor of matrix metalloproteinases (MMP).

MMP Inhibitor II (CAS 203915-59-7)

MMP Inhibitor II | CAS 203915-59-7 is rated 5.0 out of 5 by 1.
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Alternate Names: Matrix Metalloproteinase Inhibitor II; NHDDPC; PG 117025; PGE 4410186
Application: MMP Inhibitor II is a potent and reversible inhibitor of matrix metalloproteinases (MMP)
CAS Number: 203915-59-7
Purity: 95%
Molecular Weight: 513.6
Molecular Formula: C21H27N3O8S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MMP Inhibitor II is a potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).


References

Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).Requires vigorous vortexing for 60 seconds to completely solubilize the product.
Storage :
Store at -20° C
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
MMP-1: IC50 = 24 nM; MMP-3: IC50 = 18.4 nM; MMP-7: IC50 = 30 nM; MMP-9: IC50 = 2.7 nM
Ki Data :
MMP-7: Ki= 30 nM (human); MMP-1: Ki= 24 nM (human); MMP-9: Ki= 30 nM (human); MMP-3: Ki= 18 nM (human)
pK Values :
pKa: 9.53
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4218
MDL Number :
MFCD02683957
SMILES :
CC1(CN(C(N(C1)S(=O)(=O)C2=CC=C(C=C2)OC)C(=O)NO)S(=O)(=O)C3=CC=C(C=C3)OC)C

Download SDS (MSDS)

Certificate of Analysis

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MMP Inhibitor II (CAS 203915-59-7)  Product Citations

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PMID: # 29617457  PLoS ONE. e0195526.

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Rated 5 out of 5 by from MMP Inhibitor II was reported as a powerful MMP Inhibitor II was reported as a powerful and broad range inhibitor of matrix metalloproteinases. -SCBT Publication Review
Date published: 2015-01-25
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