MMP-9/MMP-13 Inhibitor I is a piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Reported to inhibit MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
1. Cheng, M. et al. 2000. J. Med. Chem. 43(3): 369-380. PMID: 10669564 2. Prato, M. et al. 2005. J. Immunol. 175(10): 6436-6442. PMID: 16272296
Soluble in DMSO (100 mg/ml), and methanol (1 mg/ml).
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Rated 5 out of
PratoPrato, M. et al. (PubMed 16272296) demonstrate that trophozoite-parasitized RBCs/hemozoin-fed adherent human monocytes displayed increased MMP-9 activity and protein/mRNA expression, produced TNF-alpha time-dependently, and showed higher matrix invasion ability. MMP-9 activation was specific for trophozoite/hemozoin-fed monocytes, was dependent on TNF-alpha production, and abrogated by anti-TNF-alpha Ab and by MMP-9/MMP-13 inhibitor I. -SCBT Publication Review
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