MMP-8 Inhibitor I is a potent and cell-permeable inhibitor of MMP-8 (IC50 = 4 nM). The family of MMPs (matrix metalloproteinases) are commonly known to be involved in the degradation of various extracellular matrix proteins. Overexpression of MMPs are linked to diseases such as arthritis, cancer, osteoporosis and arteriosclerosis. MMP-8, also known as neutrophil collagenase, exhibits collagen cleaving activity primarily found in connective tissue.
1. Matter, H., et al., 1999. Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis. Journal of medicinal chemistry. 42(11): 1908-20. PMID: 10354399
2. Prager, Gerald W., et al., 2004. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood. 103(3): 955-62. PMID: 14525763
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.