MMP-8 Inhibitor ICAS: 236403-25-1
MF: C17H18N2O5S
MW: 362.40
A potent, cell-permeable MMP-8 inhibitor.

MMP-8 Inhibitor I (CAS 236403-25-1)

MMP-8 Inhibitor I | CAS 236403-25-1 is rated 5.0 out of 5 by 1.
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Synonym: (3R)-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
Application: A potent, cell-permeable MMP-8 inhibitor
CAS Number: 236403-25-1
Purity: ≥95%
Molecular Weight: 362.40
Molecular Formula: C17H18N2O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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MMP-8 Inhibitor I is a potent and cell-permeable inhibitor of MMP-8 (IC50 = 4 nM). The family of MMPs (matrix metalloproteinases) are commonly known to be involved in the degradation of various extracellular matrix proteins. Overexpression of MMPs are linked to diseases such as arthritis, cancer, osteoporosis and arteriosclerosis. MMP-8, also known as neutrophil collagenase, exhibits collagen cleaving activity primarily found in connective tissue.


References

1. Matter, H., et al., 1999. Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis. Journal of medicinal chemistry. 42(11): 1908-20. PMID: 10354399
2. Prager, Gerald W., et al., 2004. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood. 103(3): 955-62. PMID: 14525763

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml).
Storage :
Store at -20° C
Melting Point :
253.58° C (Predicted)
Boiling Point :
587.74° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
MMP-8: IC50 = 4 nM
pK Values :
pKa: 8.99 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10761128
MDL Number :
MFCD02683950
SMILES :
COC1=CC=C(C=C1)S(=O)(=O)N2CC3=CC=CC=C3C[[email protected]@H]2C(=O)NO

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from MMP MMP-8 Inhibitor I was utilized in many articles as a protease inhibitor. -SCBT Publication Review
Date published: 2015-01-10
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