MMP-7 Antisense Oligonucleotide, Sodium Salt is an antimetastatic, 15-meric phosphorothioate antisense oligonucleotide (Tm = 35 °C) which suppresses MMP-7 expression at both the mRNA and protein levels. It is derived from the human MMP-7 DNA sequence in a sequence-specific manner in CaR-1, which is a human colon cancer cell line. MMP-7 Antisense Oligonucleotide, Sodium Salt also effectively inhibits metastasis of colon cancer cells (WiDr) to the liver in a nude mouse model.
Hasegawa, S., et al. 1998. Int. J. Cancer 76, 812. Momiyama, N., et al. 1998. Mol. Carcinog. 22, 57.
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