MMP-7 Antisense Oligonucleotide, Sodium SaltOligonucleotides are composed of well characterized consensus DNA sequences for specific transcription factors of interest. Mutant oligonucleotides are also available with one or more site-directed mutations for competitive gel shift assays.

MMP-7 Antisense Oligonucleotide, Sodium Salt

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Application: A suppressor of MMP-7 activity
Purity: ≥90%
Molecular Weight: 5123.8
* Refer to Certificate of Analysis for lot specific data (including water content).
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MMP-7 Antisense Oligonucleotide, Sodium Salt is an antimetastatic, 15-meric phosphorothioate antisense oligonucleotide (Tm = 35 °C) which suppresses MMP-7 expression at both the mRNA and protein levels. It is derived from the human MMP-7 DNA sequence in a sequence-specific manner in CaR-1, which is a human colon cancer cell line. MMP-7 Antisense Oligonucleotide, Sodium Salt also effectively inhibits metastasis of colon cancer cells (WiDr) to the liver in a nude mouse model.


References

Hasegawa, S., et al. 1998. Int. J. Cancer 76, 812. Momiyama, N., et al. 1998. Mol. Carcinog. 22, 57.

Appearance :
Lyophilized
Physical State :
Solid
Sequence :
5′-GTATATGATACGATC-3′
Solubility :
Soluble in water.
Storage :
Store at -80° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD03457525

Download SDS (MSDS)

Certificate of Analysis

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