MMP-11 Antibody (SL3.05): sc-58381

MMP-11 Antibody (SL3.05) is an IgG₁ mouse monoclonal MMP-11 antibody (also designated MMP11 antibody) suitable for the detection of the MMP-11 protein of human origin by WB, IP, IF and IHC(P). MMP-11 Antibody (SL3.05) is available as the non-conjugated anti-MMP-11 antibody. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and it is expressed at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

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References:

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