ML 141A potent Cdc42 GTPase inhibitor

ML 141 (CAS 71203-35-5)

ML 141 | CAS 71203-35-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_10, d_19, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_362768, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 35ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
Application: A potent Cdc42 GTPase inhibitor
CAS Number: 71203-35-5
Purity: ≥98%
Molecular Weight: 407.49
Molecular Formula: C22H21N3O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

ML 141 is a selective, potent and reversible non-competitive inhibitor Cdc42, a Rho family GTPase member.


References

1. Surviladze, Z. et al. 2010. Probe Reports NIH. PMID: 21433396
2. Hong, L. et al. 2013. J. Biol. Chem. PMID: 23382385

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (5 mM).
Storage :
Store at 4° C
Melting Point :
185-187° C
Boiling Point :
622.93° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Rho family GTPase cdc42: IC50 = 200 nM; Trypanosoma cruzi Replication: EC5050 = 2829 nM; Ras-related protein Rab-2: EC5050 = 704 nM; Cell division cycle 42: EC5050 = 3198 nM (human)
pK Values :
pKa: 10.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2950007
MDL Number :
MFCD05987165
SMILES :
O=S(=O)(c1ccc(cc1)N4/N=C(/c2ccccc2)CC4c3ccc(OC)cc3)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ML 141  Product Citations

See how others have used ML 141. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29934528  Khanna, P. et al. 2018. Sci Rep. 8: 9511.

PMID: # 28122282  Chien, WW. et al. 2017. Leuk. Res. 55: 41-48.

PMID: # 28383550  Wassermann-Dozorets, R. et al. 2017. Cell Death Dis. 8: e2733.

PMID: # 26943325  Li, Z. et al. 2016. Cell Death Differ.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 223ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Guo Y; et al Guo Y; et al. (PubMed ID: 26206334) determined that ML 141, is a small molecule inhibitor of Cdc42 and RAC1, both of which are commonly over expressed in ovarian cancer. -SCBT Publication Review
Date published: 2015-04-08
  • y_2019, m_10, d_19, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_362768, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 89ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.