MK-2 Inhibitor IIIA cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor

MK-2 Inhibitor III (CAS 1186648-22-5)

MK-2 Inhibitor III | CAS 1186648-22-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_10, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_221948, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 186ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
Application: A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor
CAS Number: 1186648-22-5
Purity: ≥97%
Molecular Weight: 358.39
Molecular Formula: C21H16N4O•H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

MK-2 Inhibitor III is a cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MAPKAPK-2 (MK-2), PRAK(MK-5), and 3pK(MK-3), respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 μM).


References

Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml).
Storage :
Store at 4° C
Boiling Point :
784.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
MAPKAPK-2 : IC50 = 8.5 nM; PRAK: IC50 = 81 nM; 3pK: IC50 = 210 nM; LPS-induced TNF-α production: IC50 = 4.4 µM (U937 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25163932
SMILES :
C1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

MK-2 Inhibitor III  Product Citations

See how others have used MK-2 Inhibitor III. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26505478  Matsuzaki, H. et al. 2015. PLoS ONE. 10: e0141746.

PMID: # 23657501  Mao, X. et al. 2014. J. Invest. Dermatol. 134: 68-76.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 176ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Soukup et al Soukup et al. (PubMed ID 26078274) found that MK-2 Inhibitor III inactivated MK2-mediated p38 inhibition and enabled dendritic cells to strengthen proinflammatory mechanisms by potentiating IL-1 -mediated Th1 activity in mice with encephalomyelitis. -SCBT Publication Review
Date published: 2015-05-02
  • y_2019, m_11, d_10, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_221948, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 72ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.