MJ33An active site-directed, specific, competitive, and reversible inhibitor of PLA2

MJ33 (CAS 199106-13-3)

MJ33 | CAS 199106-13-3 is rated 5.0 out of 5 by 1.
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Synonym: MJ33 Lithium salt; 1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol lithium
Application: An active site-directed, specific, competitive, and reversible inhibitor of PLA2
CAS Number: 199106-13-3
Purity: ≥90%
Molecular Weight: 498.48
Molecular Formula: C22H43F3O6P•Li
* Refer to Certificate of Analysis for lot specific data (including water content).
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MJ33 is a novel active site-directed, specific, competitive, and reversible inhibitor of phospholipase A2 (PLA2). MJ33 has inhibitory activity against a low pH calcium-independent PLA2 as well as against the PLA2 activity responsible for permeability barrier homeostasis or esophagitis.


References

1. Sekar, K., et al., Biochemistry 36, 14186 (1997) 2. Man, M.-Q., et al., J. Invest. Dermatol. 106, 57, (1996) 3. Gelb, M.H., et al., FASEB J. 8, 916, (1994) 4. Fisher, A.B., et al., Biochem. J. 288, 407, (1992) 5. Jain, M.K., et al., Biochemistry 30, 7306, (1991) 6. Jain, M.K., et al. Biochemistry 30, 10256, (1991) 7. Fisher, A.B., et al., Am. J. Physiol. 267, L335 (1994) 8. Wang, R. et al., Biochem J. 304, 131 (1994) 9. Fisher, A.B., et al., Am. J. Physiol. 272, L238 (1997)

Physical State :
Solid
Solubility :
Soluble in water (3 mg/ml).
Storage :
Store at -20° C
Boiling Point :
522.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4214
MDL Number :
MFCD03787978
SMILES :
[Li+].CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(=O)([O-])OC

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Certificate of Analysis

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MJ33  Product Citations

See how others have used MJ33. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26567374  Hernandez-Anzaldo, S. et al. 2015. J Am Heart Assoc. 4:

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Benipal Benipal, B. et al. (PubMed 25637741) reported that inhibition of the phospholipase A2 activity of peroxiredoxin 6 by MJ33, prevents lung damage with exposure to hyperoxia. -SCBT Publication Review
Date published: 2015-04-23
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