MitotaneAn adrenal cytotoxic agent

Mitotane (CAS 53-19-0)

Mitotane | CAS 53-19-0 is rated 5.0 out of 5 by 1.
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Synonym: (2,4′-Dichlorodiphenyl)dichloroethane; o,p′-DDD
Application: An adrenal cytotoxic agent
CAS Number: 53-19-0
Purity: 98%
Molecular Weight: 320.04
Molecular Formula: C14H10Cl4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mitotane, or o,p'-DDD, is a derivative of DDT (sc-238975) with antiproliferative properties. A study of the antiproliferative effects of Mitotane demonstrated particular efficacy against adrenocortical carcinoma.


References

1. Haq, M.M., et al. 1980. Cancer Treat Rep. 64: 909-913. PMID: 7448828
2. Luton, J.P., et al. 1990. N. Engl. J. Med. 322: 1195-1201. PMID: 2325710

Physical State :
Solid
Solubility :
Soluble in DMSO (≥ 64 mg/ml), ethanol (≥ 64 mg/ml), and water (< 1 mg/ml).
Storage :
Store at room temperature
Melting Point :
75-81° C (lit.)
Boiling Point :
398.88° C at 760 mmHg (Predicted)
Density :
1.37 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4211
MDL Number :
MFCD00000850
EC Number :
200-166-6
SMILES :
ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=C(Cl)C=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Mitotane  Product Citations

See how others have used Mitotane. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28739698  Park, Y.|Son, JY.|Lee, BM.|Kim, HS.|Yoon, S.| et al. 2017. Anticancer Res. 37: 4139-4146.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Luton et al Luton et al. (PubMed ID 2325710) showed that mitotane is an adrenal cytotoxic agent that controls hormonal secretions in adrenocortical carcinoma and could be used to mitigate endocrine symptoms without having a significant effect on survivability. -SCBT Publication Review
Date published: 2015-05-02
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