Mitomycin C (4% in NaCl)A DNA crosslinking and damaging agent

Mitomycin C (4% in NaCl) (CAS 50-07-7 (non-salt))

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 146ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: A DNA crosslinking and damaging agent
CAS Number: 50-07-7 (non-salt)
Molecular Weight: 334.33 (w/o NaCl)
Molecular Formula: C15H18N4O5 xNaCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Mitomycin C (4% in NaCl) is a reagent used to generate mitotically inactive feeder cells in culture. Mitomycin C (4% in NaCl) is a DNA crosslinking agent which inhibits DNA synthesis and causes apoptosis via a p53-dependent pathway. This compound is activated by sodium dithionite which is thought to cause bifunctional alkylation of DNA. In addition, when added to Micrococcus luteus DNA Mitomycin C (4% in NaCl) forms adducts between itself and deoxyguanosine residues.


1. Tomasz, M., et al. 1987. Science. 235: 1204-1208. PMID: 3103215
2. Verweij, J. and Pinedo, H.M. 1990. Anticancer Drugs. 1: 5-13. PMID: 2131038
3. Armstrong, M.J., et al. 1992. Mutat. Res. 265: 45-60. PMID: 1370242
4. Sartorelli, A.C., et al. 1994. Oncol. Res. 6: 501-508. PMID: 7620218
5. Johnson, W.S., et al. 1995. Bioorg. Med. Chem. 3: 851-860. PMID: 7582961
6. Tomasz, M. 1995. Chem. Biol. 2: 575-579. PMID: 9383461
7. Tomasz, M. and Palom, Y. 1997. Pharmacol. Ther. 76: 73-87. PMID: 9535170
8. Nieto, A., et al. 2007. Cell Biol. Int. 31: 269-278. PMID: 17241790
9. Gao, K., et al. 2008. Cell Biochem. Funct. 26: 900-907. PMID: 18956479

Usage :
• This product is supplied as a 50mg vial (2mg Mitomycin C and 48mg of NaCl)
Formulation :
4% in NaCl (2 mg Mitomycin C and 48 mg NaCl)
Appearance :
Physical State :
Derived From :
Streptomyces caespitosus
Solubility :
Soluble in water (1 mg/ml), methanol, acetone, butyl acetate, cyclohexanone, benzene, CCl4 (Slightly), and diethyl ether (Slightly). Insoluble in petroleum ether.
Storage :
Store at 4° C
Melting Point :
>360° C
Refractive Index :
n20D 1.68
IC50 :
WiDr: IC50 = 10 nM (human); K562: IC50 = 15.8 nM (human); CAKI-1: IC50 = 40 nM (human); HT-29: IC50 = 40 nM (human); SW480: IC50 = 7 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Merck Index :
14: 6215
MDL Number :
EC Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 138ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 25ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.