Mitomycin AAn antitumor and antibiotic analog of Mitomycin C

Mitomycin A (CAS 4055-39-4)

Mitomycin A | CAS 4055-39-4 is rated 5.0 out of 5 by 1.
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Application: An antitumor and antibiotic analog of Mitomycin C
CAS Number: 4055-39-4
Molecular Weight: 349.34
Molecular Formula: C16H19N3O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mitomycin A is the 6-methoxy analog of Mitomycin C (sc-3514) which possesses antitumor and antibiotic properties.


References

Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971)
Kishi, Y., et al.: J. Nat. Prod., 42, 549 (1979)

Physical State :
Solid
Solubility :
Soluble in methanol, chloroform, Benzene, water, and toluene.
Storage :
Store at -20° C
Melting Point :
159-161° C (dec.)
Boiling Point :
~587.4° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
A549: IC50 = 17.18 nM (human); HCT-8: IC50 = 17.18 nM (human); HepG2: IC50 = 22.90 nM (human); KB: IC50 = 22.90 nM (human); U-87 MG: IC50 = 25.76 nM (human)
pK Values :
pKa: 13.27 (Predicted), pKb: 5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CN1050000
PubChem CID :
19972
MDL Number :
MFCD09842550
SMILES :
COC1=C(C)C(=O)C2=C([C@@H](COC(N)=O)[C@@]3(OC)[C@H]4N[C@H]4CN23)C1=O

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Certificate of Analysis

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Kindly share me a quote for Mitomycin A for quantity 10 mg and 50 mg. i hope the material will be supplied along with analytical data (HPLC, Mass, NMR etc) with COA.

Asked by: Dharmesh Bhatt
Thank you for your question. The product is currently in stock. We offer over night shipment to many locations. Please contact our Customer Service department to place a product order or to ask for a sales quotation inlcuding delivery time.
Answered by: Technical Support
Date published: 2018-11-26
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Rated 5 out of 5 by from Sami et al Sami et al. (PubMed ID 2918519) showed that Mitomycin A exhibited antitumor activity via DNA synthesis inhibition. -SCBT Publication Review
Date published: 2015-06-21
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