Misoprostol (free acid)A PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors

Misoprostol (free acid) (CAS 112137-89-0)

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Application: A PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors
CAS Number: 112137-89-0
Purity: ≥97%
Molecular Weight: 368.5
Molecular Formula: C21H36O5
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Misoprostol, a synthetic E prostaglandin, has been shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. Additionally, This compound has been shown to have negative effects on the murine nervous system by altering the intracellular calcium levels in neuroblastoma cells. Other experiments have noted that Misoprostol has the ability to affect serum concentration of β2-microglobulin, which is related to antigen presentation on hepatocyte surface.


References

1. Graham, D.Y., et al. 1988. Lancet. 2: 1277-1280. PMID: 2904006
2. Flisiak, R., et al. 1999. Eur J Gastroenterol Hepatol. 11: 1227-1230. PMID: 10563531
3. Henriques, A., et al. 2007. Obstet Gynecol. 109: 489-490. PMID: 17267868
4. Tamiji, J., et al. 2010. Biochem. Biophys. Res. Commun. 399: 565-570. PMID: 20678471

Formulation :
A solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in methanol, PBS PH 7.2 (~1.6 mg/ml), DMSO (~50 mg/ml), ethanol (~50 mg/ml), and DMF (~50 mg/ml).
Storage :
Store at -20° C
Boiling Point :
57° C
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
relax fetal rabbit ductus arteriosus: EC5050 = 0.36 nM (rabbit); Superoxide generation : EC5050 = 0.35 µM (human neutrophils)
pK Values :
pKa: 4.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6436406
MDL Number :
MFCD00869984
Beilstein Registry :
3
SMILES :
CCCCC(C)(CC=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O

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Certificate of Analysis

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